Created by Act of Parliament and became functional effective 01 July 2010, Serere District is a district in Eastern Uganda. It's named after its 'chief town', Serere, where the district headquarters are located.

 The district headquarters at Serere are located approximately 28 kilometres, by road, south of Soroti town. This location is approximately 280 kilometres from Kampala via Ngora-Pallisa and approimately 360 Kilometres via Soroti-Mbale. The district lies within the Lake Kyoga Basin.